The Rum Diary
There arguably hasn't been a more infamous Hollywood couple in the 21st century than Johnny Depp and Amber Heard, who met on the set of 2011 drama The Rum Diary.
Not long afterwards Depp left long-term partner Vanessa Paradis. He married Heard in 2015, but Heard filed for divorce just 15 months later, and an ugly media circus ensued.
Mr. & Mrs. Smith
When they co-starred on 2005 action rom-com Mr. & Mrs. Smith, Brad Pitt was married to Jennifer Aniston, whilst Angelina Jolie had not long since divorced Billy Bob Thornton.
Pitt's marriage to Aniston soon ended, and he and Jolie began a long-term relationship. They would eventually tie the knot in 2014, but divorced five years later.
Days of Thunder
1990 race car drama Days of Thunder is now best remembered as the movie on which Tom Cruise - then still with first wife Mimi Rogers - met Nicole Kidman.
Reports state Cruise and Rogers' relationship had already been crumbling. Meeting Kidman proved the catalyst that ended it: they soon divorced, and later that same year Cruise and Kidman married.
Mary Shelley's Frankenstein
Kenneth Branagh and Emma Thompson married in 1989 and appeared in four films together. However, on 1994's Mary Shelley's Frankenstein, Branagh had a new on-screen love interest: Helena Bonham Carter.
Sparks flew off-camera as well as on, leading Branagh and Thompson to divorce. Branagh and Bonham Carter then became a couple for five years, but eventually split in 1999.
Cleopatra
When legendary couple Richard Burton and Elizabeth Taylor met on the set of 1963's Cleopatra, both were married: Burton to first wife Sybil Williams, Taylor to fourth husband Eddie Fisher.
An infamously turbulent romance ensued: Burton and Taylor married in 1964, divorced in 1974, then re-married in 1975 only to divorce again in 1976.
The Misfits
Esteemed writer Arthur Miller and superstar Marilyn Monroe seemed an unlikely couple when they wed 1956. The troubled marriage (Miller's second, Monroe's third) finally fell apart on 1961's The Misfits.
Written by Miller, The Misfits endured a troubled shoot in part due to Monroe's substance abuse and mental health issues. She divorced Miller shortly before the film opened.
The Outlaw Josey Wales
Clint Eastwood married first wife Maggie Johnson since 1953, but they separated in 1975, during production on The Outlaw Josey Wales, when Eastwood began seeing co-star Sondra Locke.
Locke then became Eastwood's muse for time. Still, Eastwood's divorce from Johnson wasn't finalized until 1984 - by which time he was already cheating on Locke with multiple women.
Gigli
In 2003, Jennifer Lopez and Ben Affleck co-starred in critically reviled comedy thriller Gigli, and soon enough the gossip columns couldn't stop talking about them.
On top of being considered one of the worst movies ever, Gigli also kickstarted 'Bennifer' - even though Lopez was still with second husband Cris Judd at the time.
Green Lantern
2011 superhero movie Green Lantern wasn't the hit the filmmakers expected, but it did achieve something of note: introducing Ryan Reynolds and Blake Lively to one another.
Reynolds was married to fellow on-screen superhero Scarlett Johansson at the time. They divorced in late 2010, and soon thereafter Reynolds and Lively were an item, marrying in 2012.
Dream House
2011 horror movie Dream House would most likely be forgotten today were it not for the role it played in forging another Hollywood golden couples, Daniel Craig and Rachel Weisz.
Weisz soon divorced director Darren Aronofsky, whilst Craig called it quits with his fiancé, producer Satsuki Mitchell. They married that year and now have two children.
To Have and Have Not
When work began on 1944's To Have and Have Not, Humphrey Bogart was 44 and married to fourth wife Mayo Methot, whilst Lauren Bacall was a 19-year-old first-time actress.
An illicit romance ensued, and it wasn't long before Bogart had divorced Methot and tied the knot with Bacall. They stayed together until Bogart passed away in 1957.
Titanic
James Cameron may be great at making blockbusters, but he hasn't always been so good at marriage. By 1997, he was on his fourth wife - Terminator leading lady Linda Hamilton.
After Cameron got close to Titanic actress Suzy Amis, he and Hamilton divorced in 1999. Amis became the fifth Mrs. Cameron in 2000, and they're still together.
The Getaway
When Steve McQueen met Ali MacGraw on 1972 thriller The Getaway, sparks flew off-camera as well as on - despite the fact that both of them were married.
McQueen soon divorced first wife Neile Adams, whilst MacGraw divorced producer Robert Evans. They wed in 1973, but were divorced by 1978, two years before McQueen died.
Planet of the Apes (2001)
After divorcing only wife Lena Gieseke in 1991, director Tim Burton began seeing Lisa Marie, who he cast in several films - including 2001's Planet of the Apes.
Another actress Burton cast in Planet of the Apes was Helena Bonham Carter - and after falling for her, the director soon parted ways with Lisa Marie.
Snow White and the Huntsman
Kristin Stewart was at the height of her Twilight fame, and dating her equally famous co-star Robert Pattinson, when she made Snow White and the Huntsman.
The film's director, Rupert Sanders, was married at the time to model Liberty Ross. However, an affair with his leading lady ensued, for which both Sanders and Stewart publicly apologized.
Street Fighter
Beefy Belgian Jean-Claude Van Damme was married to fourth wife Darcy LaPier, when he appeared alongside Australian singer and actress Kylie Minogue, in 1994's Street Fighter.
Van Damme flatly declared in 2012, "It would be abnormal not to [...] She's so beautiful..." His marriage to LaPier ended in divorce in 1997.
Star Wars
1977's Star Wars may have sent Harrison Ford's film career into lightspeed, but it also helped end his first marriage, thanks to an affair with co-star Carrie Fisher.
Fisher (who later described the affair as a "three-month one-night stand") was 19 at the time, whilst Ford was 33. His marriage to Mary Marquadt ended in divorce in 1979.
You, Me and Dupree
Actress Kate Hudson had been married to singer-songwriter Chris Robinson of The Black Crowes for six years when she met Owen Wilson on 2006 comedy You, Me and Dupree.
Divorcing Robinson in 2007, Hudson dated Wilson on-and-off for three years. Infamously, this was a very difficult period for Wilson, who struggled with substance abuse, and attempted suicide in 2007.
Planet Terror
Filmmaker Robert Rodriguez began seeing actress Rose McGowan on his 2007 film Planet Terror - even though he was still married to producer Elizabeth Avellán at the time.
Rodriguez and Avellán divorced in 2007 after 17 years of marriage, in which time they had five children. He remained in a relationship with McGowan until 2009.
Eyes Wide Shut
As well as being the third film Tom Cruise and Nicole Kidman made together (after Days of Thunder and Far and Away), 1999's Eyes Wide Shut also soured their relationship.
Although Kidman herself has dismissed this, it has been widely speculated that the psychological strain of making the film was a key factor in her subsequent divorce from Cruise.
Rosemary's Baby
Actress Mia Farrow was 21, 29 years the junior of legendary entertainer Frank Sinatra, when she became his third wife in 1966, but they fell out over 1968's Rosemary's Baby.
Farrow's commitment to Rosemary's Baby forced her to drop out of Sinatra's film The Detective. When Farrow refused Sinatra's demand she quit the film, he divorced her.
Pushing Tin
Angelina Jolie and Billy Bob Thornton met on 1999 comedy drama Pushing Tin. Thornton had already been married four times and was dating Laura Dern at the time.
They wed in 2000 (he was Jolie's second husband, after Jonny Lee Miller), but split within three years. Thornton married sixth wife Connie Angland in 2014, and they're still together.
Daredevil
When Ben Affleck and Jennifer Garner worked together on 2003 superhero movie Daredevil, Garner was married to Scott Foley whilst Affleck was famously dating Jennifer Lopez.
Affleck and Garner had already worked together on 2001's Pearl Harbor, but playing screen lovers in Daredevil rubbed off on them. They left their significant others and wed in 2005.
The Shining
In 1978, actress Shelley Duvall was dating famed singer-songwriter Paul Simon. Then, just as she was leaving for England to start filming The Shining, Simon broke up with her.
Duvall arrived to the set of The Shining shell-shocked and vulnerable. Shooting the intense film only made this worse, contributing to the mental health issues Duvall has suffered since.
Proof of Life
2000's Proof of Life gave Russell Crowe one of his first major roles after Gladiator - but it was also one of the last major movies to star Meg Ryan.
They had an affair during the shoot, whilst Crowe was seeing Danielle Spencer and Ryan was married to Dennis Quaid. Ryan and Quaid soon divorced, though Crowe and Spencer reconciled.
Made in America
In 1993, Ted Danson joined Whoopi Goldberg in Made in America. An affair began, despite the fact that Danson was still married to second wife Cassandra Coates.
When Coates took $30 million from Danson in their divorce settlement, it was one of the most expensive Hollywood splits ever. Danson and Goldberg then dated for around 18 months.
Chasing Amy
Joey Lauren Adams first worked with writer-director Kevin Smith on his 1995 comedy Mallrats. They began dating, and Smith wrote his follow-up movie Chasing Amy specifically for Adams.
The writer-director spoke openly about how their romance influenced the film's frank sexual discussions. This might have been more information than Adams wanted to share, as she soon left him.
Someone's Watching Me!
Director John Carpenter rose to fame with 1978's Halloween, co-written and produced by his then-girlfriend Debra Hill. Carpenter then made TV movie Someone's Watching Me! which co-starred Adrienne Barbeau.
Carpenter left Hill, and married Barbeau in 1979. She would go on to appear in two more of his films, and they had one child together before divorcing in 1984.
Mind Over Murder
Tori Spelling was married to Charlie Shanian and Dean McDermott was married to Mary Jo Eustace when they met, and had an affair, on 2005 TV movie Mind Over Murder.
Spelling and McDermott proceeded to divorce their significant others. They married in 2006, and are legally still together but reportedly separated today.
Children of a Lesser God
On 1986's Children of a Lesser God, William Hurt dated co-star Marlee Matlin. Her performance won her the Best Actress Oscar - and Hurt presented her the award.
However, while Hurt outwardly showed pride in Matlin, she later revealed he was very different in private, subjecting her to emotional and physical abuse. They split within two years.
Dangerous Liaisons
1988 period drama Dangerous Liaisons revolves around the affairs of French aristocrats - so perhaps its only fitting that actors Michelle Pfeiffer and John Malkovich had an affair for real.
This dalliance resulted in the collapse of Malkovich's marriage to Glenne Headly, whilst Pfeiffer was also soon divorced from Peter Horton.
The Last Picture Show
Director Peter Bogdanovich's acclaimed 1971 hit The Last Picture Show was a breakthrough film for actress Cybill Shepherd. The director and actress embarked on an affair during production.
This led to the collapse of Bogdanovich's marriage to first wife Polly Platt, which made things especially tense as Platt was also the film's production designer.
mother!
Director Darren Aronofsky began dating actress Jennifer Lawrence when she appeared in his 2017 movie Mother! Lawrence has admitted the critical fallout over the controversial film led to their split.
Lawrence and Aronofsky were still dating whilst promoting Mother! at the time of its release, but the strain of the negative feedback took its toll and Lawrence ended things.
The Break-Up
The actors who appear in a movie called The Break-Up begin dating - and then actually break up? Has life ever imitated art so acutely?
Vince Vaughn and Jennifer Aniston were seeing each other when they co-starred in the 2006 romantic comedy drama, but the relationship ended soon afterwards.
Silence
Emma Stone and Andrew Garfield were a couple when they co-starred in the two Amazing Spider-Man movies, but Garfield's role in Martin Scorsese's Silence wound up sinking the relationship.
Garfield threw himself into the film, losing weight and researching the role so heavily that he had no time left for Stone. This proved to be the final straw.
Gone Girl
Emily Ratajkowski co-starred in 2014's Gone Girl as the young mistress of Ben Affleck's character - and it's rumored the actors enjoyed a similar relationship off-camera.
While it has never been confirmed that this was the case, there's widespread speculation that Jennifer Garner later filed for divorce from Affleck at least in part because of Ratajkowski.
Allied
Brad Pitt had been married to Angelina Jolie for two years when he co-starred with Marion Cotillard on 2016's Allied - where, according to rumor, an affair ensued.
Reports claimed that Jolie had Pitt followed by a private investigator and later confronted him over the matter. Their relationship soon broke down, ending in divorce in 2019.
House of Wax
2005 slasher movie House of Wax features Paris Hilton and Chad Michael Murray, who - standard for the genre - play horny youngsters. They didn't just do this on camera.
Murray's cheating with Hilton is said to have ended his relationship with Sophia Bush - which was awkward, as Murray and Bush played a couple on TV's One Tree Hill.
Stage Beauty
When Billy Crudup and Claire Danes played lovers in 2004's Stage Beauty, a real affair ensued - even though Crudup was spoken for.
The ensuing relationship (which lasted until 2006) attracted criticism as Crudup walked out on long-term girlfriend Mary Louise Parker, who was pregnant with his child at the time.
Stop-Loss
Ryan Phillippe had been married to his Cruel Intentions costar Reese Witherspoon since 1999, but on 2008's Stop-Loss he started an illicit romance with another co-star, Abbie Cornish.
Witherspoon and Phillippe soon divorced. Phillippe was then with Cornish for a time, but their romance came to an end in 2010.
By The Sea
A decade after shooting Mr and Mrs Smith, Angelina Jolie and Brad Pitt costarred in 2015's By The Sea.
Before production started, Jolie claimed the film would be a test of their marriage. It seems the test failed and, barely a year after production wrapped, the pair officially divorced.
Two Much
In 2014, Antonio Banderas and Melanie Griffith filed for divorce, marking the end of a decades-long romance that had begun while they were both married to other people.
The pair met while costarring in 1995's Two Much, and their mutual attraction proved too much to resist, with divorces and remarriage taking place within a year.
Wanderlust
While they'd never officially married, Justin Theroux and Heidi Bivens had been in a relationship for 14 years when the former met Jennifer Aniston on the set of Wanderlust.
A few months after production wrapped, Theroux called it quits with Bivens and started publicly dating Aniston, with the pair tying the knot in 2015 before divorcing two years later.
Northern Lights
Eddie Cibrian and LeAnn Rimes embarked on a steamy affair during production of 2009's Northern Lights, and they weren't exactly subtle about it.
Us Weekly released a series of snaps of the pair getting intimate in a restaurant, bringing Cibrian's eight-year marriage to Brandi Glanville to a dramatic end.
Terminator 2: Judgement Day
The relationship between Linda Hamilton and James Cameron ended with infidelity, and it began with it, too.
The couple embarked on an affair while working on Terminator 2: Judgement Day, ending Cameron's marriage to fellow director Katherine Bigelow, although - despite the nature of the split - the two remained friends.
Shanghai Surprise
While Sean Penn and Madonna were still married when they costarred in 1986's Shanghai Surprise, their relationship was reportedly already on the rocks.
Working closely together only exacerbated existing problems, and the couple filed for divorce a few months after the movie hit theaters.
Zoolander 2
While it's never been officially confirmed, there's been a lot of speculation that the stresses of working together on Zoolander 2 pushed Ben Stiller & Christine Taylor to get divorced.
The couple announced their split less than a year after the movie was released, although they're reportedly still on good terms.
Phantasmagoria: The Visions of Lewis Carroll
Although it was never released, Phantasmagoria: The Visions of Lewis Carroll was Marilyn Manson's predictably grotesque take on Alice in Wonderland.
The project was canned after its trailer sparked a furor, and the incident apparently pushed Manson's then-wife - burlesque dancer Dita Von Teese - over the edge, as she quickly filed for divorce.
Fosse/Verdon
Michelle Williams tied the knot with musician Phil Elverum in 2016, but the marriage only lasted for a few years.
After Williams started working on Fosse/Verdun, it didn't take long for her to start dating director Thomas Kail, with both leaving their spouses not long after.
Underworld
While Kate Beckinsale wasn't married when she started working on Underworld, she was in a committed relationship with Michael Sheen, with whom she had a baby.
Director Len Wiseman, on the other hand, had been married for several years. In the end, neither let their commitments hold them back, and they soon left their partners for each other.
The Last Face
If there's a lesson Sean Penn should have learned by now, it's that working with romantic partners never seems to end well for him.
Penn and Charlize Theron costarred in The Last Face in 2014, shortly after getting engaged. Production of the movie was incredibly stressful, and by the time shooting had wrapped, the relationship was done.
Layer Cake
While it wasn't the first time their relationship had been rocked by infidelity, Sienna Miller & Jude Law finally broke up after the former cheated with Daniel Craig.
The affair started while Miller and Craig were costarring in 2004's Layer Cake, with Law finding out after Miller's driver tipped him off.
Nymphomaniac
Considering Nymphomaniac boasts some of the raunchiest scenes in the history of cinema, it's no surprise that production led to some real-life liasons.
Most notable was the affair between Shia LaBeouf and Mia Goth, which resulted in LaBeouf breaking off his long-term relationship with stylist Karolyn Pho.
Don't Worry Darling
When Shia LaBoeuf dropped out of 2022's Don't Worry Darling, Olivia Wilde cast Harry Styles in his place. It would prove to be a momentous decision, with dramatic ramifications.
During production, Wilde and Styles ending up falling for each other, with Wilde divorcing her husband Jason Sudeikis a few months later.
Honey Boy
Only a few years after cheating with Mia Goth on the set of Nymphomaniac, Shia LaBoeuf cheated on her while working on 2019's Honey Boy.
LaBoeuf became romantically entangled with costar FKA Twigs, with the pair beginning a relationship that would end with accusations of abuse and a lawsuit.
Woman of the Year
In 1942, Spencer Tracy and Katherine Hepburn indulged in a fling while producing Woman of the Year, starting a messy, complicated affair that would last for 26 years.
While Tracy and his wife didn't divorce, he did move out of the family home. He also stayed romantically involved with Hepburn, who apparently was uninterested in a more stable or official relationship.
Spider-Man: No Way Home
Andrew Garfield and Emma Stone got together after costarring in 2012's The Amazing Spider-Man, but the franchise would eventually break them up, too.
After Garfield reprised his role in 2021's Spider-Man: No Way Home, production involved spending long stretches of time away from Stone, with the couple eventually drifting apart.
Wicked
In 2023, Ariana Grande and Ethan Slater made headline news when they left their respective partners and began publicly dating.
The pair have remained tight-lipped about how they got together, but it's widely believed that sparks started to fly during production of Wicked.
The Break-Up
In 2006, Jennifer Aniston and Vince Vaughn started dating, creating a celebrity couple that absolutely no one saw coming.
In a classic case of life imitating art, the pair split less than a year later while costarring in The Break-Up.
The Mexican
Julia Roberts was starring in 2001's The Mexican when she fell for cameraman Danny Moder. The pair began an affair, despite the fact that Roberts was in a relationship and Moder was married.
In the end, the couple decided to leave their partners and make it official, and they're still happily married today.
A Star is Born
Lady Gaga and Bradley Cooper gave a live performance at the 2019 Oscars, with their obvious chemistry fueling rumors they'd had an affair while filming A Star is Born.
Both stars have adamantly claimed they never became intimate, but Cooper's split from his girlfriend shortly after production wrapped has been interpreted by many as confirmation that something happened.
The Hunger Games
Although everyone involved has remained secretive about what really went down, fans have long speculated that Liam Hemsworth cheated on Miley Cyrus with Jennifer Lawrence when they costarred in The Hunger Games.
The flames of gossip were further fanned by Cyrus' record Flowers, which alludes to Hemsworth's infidelity and was released on Lawrence's birthday.
Focus
While 2015's Focus was still in production, paparazzi caught snaps of Will Smith and Margot Robbie getting very cosy indeed at a cast party.
Smith and his wife Jada Pinkett are still together, but in recent years their marriage has seemed increasingly turbulent. Coincidence? Probably, but then again, maybe not.
Dukes of Hazard
In 2020, Jessica Simpson released her memoir, finally shedding light on the reason for her divorce from singer Nick Lachey.
According to Simpson, she and Johnny Knoxville embarked on an "emotional affair" during the production of 2005's Dukes of Hazard, in which they were costarring.
The Town
Ben Affleck has something of a reputation for getting romantically entangled with his costars, so it's not particularly surprising that there was gossip of an affair with Blake Lively during production of The Town.
Although the rumors remain unsubstantiated, Affleck's ex-wife Jennifer Garner has made plenty of cryptic comments alluding to the fact that the actor has a hard time remaining faithful.
Smash
In 2012, Debra Messing divorced her husband of 16 years, director and producer Daniel Zelman. Soon after, she was seen in public with her Smash costar Will Chase, sparking rumors of an affair.
Messing has claimed that she and Zelman had already decided to split before she became entangled with Chase, but many find the timing to be suspicious.
Passengers
In 2016, Jennifer Lawrence once more found herself embroiled in a cheating scandal, this time involving her Passengers costar Chris Pratt.
Lawrence has consistently brushed off the rumors, but plenty of fans are still convinced she's the real reason Pratt and Anna Faris ended up getting divorced.
Palmer
In 2019, Justin Timberlake and his Palmer costar Alisha Wainwright were snapped holding hands and flirting on a drunken night out.
Timberlake publicly apologized to his then-pregnant wife Jessica Biel, and - while it didn't quite ruin their relationship - it undoubtedly made it pretty tense for a while.
Rebecca
When Armie Hammer divorced his wife in 2021, rumors immediately spread that Lily James was a part of the situation.
The pair had recently costarred in the romantic thriller Rebecca, prompting speculation that they'd reenacted some of the movie's racier scenes in real life.
Anyone But You
The sizzling chemistry between Glen Powell & Sydney Sweeney in 2023's Anyone But You might have been due to the fact that they weren't faking their emotions.
Although both actors laughed off rumors of an affair, it seems more than a little coincidental that Powell split from his girlfriend just after production wrapped.
Morocco
Early silver screen icons Gary Cooper and Marlene Dietrich co-starred in 1930's Morocco, and got a little too close off-camera - whilst Cooper was already seeing Lupe Velez.
It's no understatement to say Velez took this personally, as not long thereafter she unsuccessfully tried to shoot Cooper as he climbed aboard a train.
Stromboli
Ingrid Bergman and director Roberto Rossellini were both married when they began an affair on 1950's Stromboli, and she was soon pregnant with his child.
The ensuing scandal almost killed her career, but Bergman eventually bounced back, and their child Isabella Rossellini became a star in her own right.
Right Now, Wrong Then
Korean filmmaker Hong Sang-Soo had been married for more than 30 years when he had an affair with actress Kim Min Hee whilst filming 2015's Right Now, Wrong Then.
Scandal ensued, and Kim Min Hee bore the brunt of this. Her career significantly suffered as job offers dried up.
State of Grace
Gary Oldman had been married to fellow British actor Lesley Manville since 1987 when he made State of Grace - where he met director Phil Joanou's then-girlfriend, Uma Thurman.
Soon thereafter, Manville and Oldman/Joanou and Thurman were history, and Oldman and Thurman were hitched. They divorced within two years, and Oldman is currently on his fifth wife.
Nine Months
Hugh Grant knew his 1995 comedy Nine Months was bad, and doomed to flop. Weeks before the film's release, the actor felt despondent, got drunk, and made some bad decisions.
Net result: Grant was arrested after being caught in public with a prostitute. While his then-fiancé Elizabeth Hurley publicly forgave him, this soured the relationship and they split in 2000.